How Autoimmune Diseases Can Hinder Mental Health

Thrive • August 25, 2022
By Thrive Wellness Reno Pediatric and Adolescent Psychiatrist Jayleen Chen, M.D. and Thrive Wellness Reno Primary Care Physician, Internal Medicine Lorrie Oksenholt, D.O. 

Autoimmune diseases affect 14.7 to 23.5 million Americans and involve abnormal functioning of the immune system which often leads to many debilitating and distressing physical ailments. Furthermore, mental health conditions may also result from autoimmune diseases and the medications used to treat them.

WHAT ARE AUTOIMMUNE DISEASES?

When operating optimally, the immune system attacks viruses, bacteria, and other harmful substances. As part of the immune system’s protection process against contaminants, white blood cells and antibodies prompt an inflammatory response that isolates foreign organisms and rids them from the body. An autoimmune disease occurs when the immune system malfunctions and begins to attack native body tissues and cells. There are over 80 different kinds of known autoimmune diseases, each of which can impact the body in unique ways. 

Common autoimmune diseases include:

  • Lupus: Occurs when the immune system attacks healthy tissues and organs, affecting many different body systems.
  • Multiple sclerosis: Occurs when the immune system attacks the protective covering of nerves, which disrupts communication between the brain and the body.
  • Psoriasis: Occurs when the immune system attacks healthy skin cells, causing a scaling, itchy, and dry skin patches to form. 
  • Rheumatoid arthritis: Occurs when the immune system attacks healthy cells in the joints, causing painful swelling. 
  • Type 1 diabetes : Occurs when the immune system attacks pancreatic cells which inhibits insulin production.
  • Vasculitis: Occurs when the immune system attacks the blood vessels, impeding circulation and potentially cutting off blood supply to different parts of the body.
  • Autoimmune diseases of the thyroid : Occur when the immune system attacks the thyroid, which can disrupt metabolic function throughout the body.

While the symptoms of autoimmune diseases vary by diagnosis, some common characteristics include: 

  • Fatigue
  • Muscle and joint pain 
  • Swollen glands
  • Fever
  • Skin irregularities
  • Abdominal pain 

AUTOIMMUNE DISEASES AND MENTAL HEALTH

Some theories that link autoimmune disorders with mental health include: 

  • Severe infection and autoimmune disease may cause mood disorders.
  • Mood disorders may create a susceptibility to infection or autoimmune disease. 
  • Mood disorders, severe infection, and autoimmune disorders may share common triggers. 

The typical symptoms of exhaustion and chronic pain brought on by many autoimmune diseases can make it difficult for a person to be happy, motivated, and productive. In addition to these concerns, autoimmune diseases and related inflammation can also contribute to a host of psychological conditions. Substances involved in the inflammatory response, such as pro-inflammatory cytokines, may contribute to:

With some autoimmune diseases, such as multiple sclerosis, the immune system attacks parts of the central nervous system that impact mood and cognition. This may lead to neurocognitive changes, such as:

  • Irritability
  • Personality changes
  • Depression
  • Psychosis, characterized by a disconnect from reality

Some medications used to treat the symptoms of autoimmune disorders can also lead to psychiatric symptoms. For example, anti-inflammatory steroids may cause symptoms of: 

  • Agitation
  • Anxiety
  • Distractibility
  • Fear
  • Hypomania , or extreme changes in mood, emotions, or energy levels
  • Apathy, lack of interest in activities one once enjoyed
  • Insomnia
  • Irritability
  • Lethargy
  • Pressured speech, or talking faster than usual
  • Restlessness

Mental health conditions can create barriers to effectively coping with autoimmune diseases and vice versa. Tending to one’s mental health with professional support can improve a person’s ability to manage life with an autoimmune disorder.  

INTEGRATED MENTAL AND PHYSICAL HEALTH CARE AT THRIVE WELLNESS

Founded in the principle that physical and mental health overlap and influence each other, Thrive Wellness’ approach to client care is collaborative, integrated, and comprehensive. Our interdisciplinary clinicians include primary care physicians, psychiatrists, therapists, occupational therapists, and dietitians who treat all aspects of individuals’ health concerns and empower them to flourish. Reach out to learn more about our health services

While all Thrive Wellness locations offer interdisciplinary clinical teams who collaborate to treat eating disorders, perinatal mood and anxiety disorders (PMADs), and additional mental and behavioral health conditions, programs and services may vary by location.

About the Authors

Thrive Wellness Reno Child and Adolescent Psychiatrist Jayleen Chen, M.D.

Dr. Jayleen Chen is a child and adolescent psychiatrist with strong Northern Nevada roots. She brings extensive clinical leadership experience to Thrive, having served as the Chief of Staff and Medical Director at child and adolescent behavioral health centers in Reno. At Thrive, she treats children and adolescents struggling with behavioral health conditions. Dr. Chen completed her bachelor’s degree, medical doctorate, psychiatry residency, and child and adolescent psychiatry fellowship at the University of Nevada, Reno. Dr. Chen enjoys spending time with her family and friends. Her interests include cooking and baking, sports, hiking, and local theater.

Thrive Wellness Reno Primary Care Physician, Internal Medicine Lorrie Oksenholt, D.O.

After earning a bachelor’s degree in foods and nutrition at Walla Walla College in Washington state, Dr. Lorrie Oksenholt attended medical school at the University of Missouri-Kansas City where she obtained her medical degree as a doctor of osteopathic medicine. She completed her internal medicine residency through the University of Nevada, Reno where she also served as a clinical professor of medicine in both inpatient and outpatient settings. Additionally, Dr. Oksenholt worked as the chief of staff and acting medical director at Nevada Mental Health.

Dr. Oksenholt has been practicing internal medicine for over thirty years and has significant experience treating general health concerns as well as issues specific to women’s health and men’s health, respectively. Throughout her career, she has worked closely with clinical specialists to treat mental and behavioral health issues, including eating disorders. She is passionate about a whole-person approach to health care that addresses the mind, body, and heart for overall well-being. As an internal medicine physician at Thrive Wellness Reno, Dr. Oksenholt finds fulfillment in working alongside caring clinicians to foster holistic health for patients. She strongly believes in the power of preventative medicine and is committed to collaborating with those in her care to achieve optimal health.

Outside of her practice, Dr. Oksenholt enjoys taking advantage of the abundance of outdoor activities that Northern Nevada has to offer. She and her husband enjoy spending time together as well as with their children and grandchildren as often as possible. Dr. Oksenholt has many hobbies including glasswork, jewelry making, and quilting.

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When Emma was 8, her parents noticed her food choices shrinking. At first, they assumed it was just picky eating — “She’ll outgrow it,” friends said. But by 10, Emma would only eat crackers, cheese, and chicken nuggets. Family dinners became nightly struggles, her growth slowed, and she skipped birthday parties to avoid “strange food.” Her parents felt powerless, her brother grew frustrated, and outings dwindled. What began as food avoidance soon reshaped the rhythm of the entire household. When children avoid food, most parents expect it’s a passing stage. But when restriction deepens, shrinks to only a few “safe foods,” and begins affecting growth or health, families suddenly find themselves in unfamiliar territory. This is often where Avoidant/Restrictive Food Intake Disorder (ARFID) emerges — with effects that extend far beyond the plate. As providers, we need to be attuned to these patterns. It’s tempting to dismiss them as “no big deal,” yet for many families, they are life-altering. Sadly, Emma’s story is not unusual. Mealtimes as Battlegrounds Families living with ARFID often describe mealtimes as emotionally charged, exhausting, and unpredictable. What should be a chance to connect around the table can feel more like a negotiation or even a standoff. Parents wrestle with whether to push their child to try a new food or give in to the same “safe foods” again and again to avoid tears, gagging, or complete meltdowns. This ongoing tension can make mealtimes dreaded rather than cherished. Siblings, too, are affected. Some may feel resentful when family meals are limited to what only one child will tolerate. Others may act out in response to the constant attention the child with ARFID receives. Over time, the dinner table shifts from a place of nourishment and bonding into a stage for conflict, anxiety, and guilt — a pattern that can erode family cohesion and resilience. Social Isolation and Missed Experiences ARFID impacts more than what happens at home; it influences how families engage with the world around them. Everyday events — birthday parties, school lunches, vacations, even extended family dinners — become sources of stress. Parents may pack special foods to avoid confrontation or, in many cases, decline invitations altogether to protect their child from embarrassment or overwhelm. This avoidance can lead to an unintended consequence: isolation. Families miss out on milestones, friendships, and traditions because of the unpredictability surrounding food. The child may feel left out or ashamed, while parents grieve the loss of “normal” family experiences. This social withdrawal can compound the anxiety already present in ARFID and deepen its impact across generations. Emotional Toll on Parents The emotional strain on parents navigating ARFID is significant. Many describe living in a constant state of worry — Will my child get enough nutrients? Will they ever grow out of this? Am I doing something wrong? This worry often spirals into guilt and self-blame, particularly when outside voices dismiss the disorder as mere “picky eating.” In addition, the pressure to “fix” mealtimes can strain marital relationships, creating disagreements over discipline, feeding strategies, or medical decisions. Parents may also feel emotionally depleted, pouring all their energy into managing one child’s needs while inadvertently neglecting themselves or their other children. Without support, this chronic stress can lead to burnout, depression, and disconnection within the family system. The Role of Providers For clinicians, ARFID must be viewed not only as an individual diagnosis but as a family-wide challenge. Effective care requires attention to both the clinical symptoms and the family dynamics that shape recovery. Parent Support: Educating caregivers that ARFID is not their fault, offering psychoeducation, and helping them reframe mealtime struggles as part of the disorder — not a parenting failure. Family-Based Interventions: Coaching families in structured meal support, communication strategies, and gradual exposure work so parents don’t feel powerless. Holistic Care: Involving therapists, dietitians, occupational therapists, and medical providers ensures that the family does not shoulder the weight of treatment alone. When families are validated, supported, and given practical tools, the entire household can begin to heal. Treatment is not only about expanding a child’s food repertoire but also about restoring peace, resilience, and connection at home. Moving Forward ARFID may begin with one individual, but its ripple effects are felt across the entire family system. By addressing both the psychological and relational dimensions, providers can help transform mealtimes from a source of conflict into an opportunity for healing and connection. For those who want to go deeper, we invite you to join our upcoming training on ARFID , where we will explore practical strategies for supporting both clients and their families.
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